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Molecular Insight into Human Platelet Antigen Hpa-1 Polymorphism
Gholamreza Anani Sarab
Molecular Insight into Human Platelet Antigen Hpa-1 Polymorphism
Gholamreza Anani Sarab
Human platelet HPA-1 polymorphism is embedded in the N-terminal plexin/semaphorin/integrin (PSI) domain of the ?3 chain of the platelet integrin ?IIb?3. HPA-1 polymorphism is responsible for neonatal alloimmune thrombocytopenia (NAITP). T-helper response drives anti-HPA-1a production and the putative dominant T-helper epitope is likely to be an important contributory factor in the immunogenicity of HPA-1a. This book provides detailed insight into the molecular mechanism behind of anti-HPA-1a platelet alloimmunization.
Mídia | Livros Paperback Book (Livro de capa flexível e brochura) |
Lançado | 12 de dezembro de 2013 |
ISBN13 | 9783659444111 |
Editoras | LAP LAMBERT Academic Publishing |
Páginas | 288 |
Dimensões | 150 × 16 × 225 mm · 426 g |
Idioma | English |
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