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Anion Receptors Based on Ion Pairing and Hydrogen Bonding: from Nitrate to Naproxen
Pascal Blondeau
Anion Receptors Based on Ion Pairing and Hydrogen Bonding: from Nitrate to Naproxen
Pascal Blondeau
This thesis reports the design and synthesis of guanidinium-based receptors as multiple hydrogen bond hosts for molecular recognition of anions with a special emphasis on small anions such as nitrate and the anti-inflammatory drug Naproxen. Despite its significant involvement in environmental pollution, little attention has been given to nitrate by supramolecular chemists. This books reports the design of several macrocycles combining a guanidinium and two urea moieties for an optimal complement of size, charge and binding sites to nitrate. Naproxen is the only Non-Steroidal Anti-Inflammatory drug (NSAID) marketed as a pure enantiomer. The industrial preparation of the drug involves the synthesis of the racemic acid followed by a resolution process to afford the desired compound (resolution accounts for two thirds of the production costs). Here, we propose as an alternative the use of a physical separation method (liquid-liquid extraction) employing a chiral receptor.
Mídia | Livros Paperback Book (Livro de capa flexível e brochura) |
Lançado | 30 de junho de 2011 |
ISBN13 | 9783844384246 |
Editoras | LAP LAMBERT Academic Publishing |
Páginas | 196 |
Dimensões | 150 × 11 × 226 mm · 310 g |
Idioma | German |
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